Ultomiris is a biologic therapy that is indicated to treat:

• adult patients with paroxsymal nocturnal hemoglobinuria (PNH)
• adults and pediatric patients one month of age and older with atypical hemolytic uremic syndrome (aHUS)

What Is Ultomiris?  

Ultomiris (ravulizumab-cwvz) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion. 

How Ultomiris Works  

 Ultomiris works by binding to the complement protein C5 to block its activation ad remove it from the bloodstream. By biding and eliminating C5, Ultomiris controls intravascular hemolysis (IVH) of paroxysmal nocturnal hemoglobinuria (PNH). 

What Is Ultomiris Used For?  

Doctors order ravulizumab-cwvz to treat: 

• adult patients with paroxysmal nocturnal hemoglobinuria (PNH) 
• adults and pediatric patients one month of age and older with atypical hemolytic uremic syndrome (aHUS) 

Ultomiris Infusion Dosage and Administration  

Patients receive ravulizumab-cwvz intravenously. Treatment time for an Ultomiris infusion at a medical clinic like IV LEAGUE INFUSION SERVICES usually lasts around 2 hours for adults and 4 hours for children. 

Dosage and Frequency  

Before receiving their first intravenous infusion of ravulizumab-cwvz, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

Ultomiris is typically administered every 8 weeks. 

Administering Ultomiris via IV Infusion  

1.  The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Ultomiris Infusion Side Effects  

As with all medications, side effects are possible. 

Common side effects include: 

• Upper respiratory tract infection  
• Headache  

Other serious side effects include: 

• Infusion-related reactions 
• Serious infections 

How To Prepare for an Ultomiris Infusion  

It is essential that patients inform their physician if they: 

• Have an infection or fever 
• Are currently taking any medications including prescription and over-the-counter medicines, vitamins, and herbal supplements 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Ultomiris IV infusion treatment at IV LEAGUE INFUSION SERVICES. 

How to Get a Referral for Ultomiris IV Infusions  

Every Ultomiris referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Ultomiris IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis Physician’s name and NPI# 
• Office address, phone, and fax numbers
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Patient has been immunized with meningococcal vaccines at least 2 weeks prior to administering the first dose of Ultomiris 
• Clinicals to support one or more of the following: 
• Patient has Paroxysmal Nocturnal Hemoglobinuria (PNH) 
• Patient has atypical Hemolytic Uremic Syndrome (aHUS) 

If you or someone you care about has one of the conditions that Ultomiris infusions treat, you may want to learn more about IV infusion treatments with ravulizumab-cwvz. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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Simponi Aria is a biologic therapy that is indicated to treat:

• moderately to severely active rheumatoid arthritis (RA) and currently taking methotrexate
• active psoriatic arthritis
• active ankylosing spondylitis

What Is Simponi Aria?   

Simponi Aria (golimumab) is a prescription tumor necrosis factor (TNF) blocker medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion.  

How Simponi Aria Works  

Tumor necrosis factor-alpha (TNF-alpha) is a substance made by the immune system. People with certain autoimmune conditions produce too much TNF-alpha, leading the immune system to attack parts of the body and cause the symptoms of certain chronic conditions. Simponi Aria works by targeting and blocking the actions of the excess TNF-alpha produced in the body. 

What Is Simponi Aria Used For?  

Doctors order golimumab to treat several medical conditions. 

Simponi Aria treats: 

• moderately to severely active rheumatoid arthritis (RA) and currently taking methotrexate 
• active psoriatic arthritis 
• active ankylosing spondylitis 

Simponi Aria Infusion Dosage and Administration  

Patients receive golimumab intravenously. Treatment time for a Simponi Aria infusion at a medical clinic like IV LEAGUE INFUSION SERVICES usually lasts for 30 minutes. 

Dosage and Frequency  

 Before receiving their first intravenous infusion of golimumab, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

The first two doses of Simponi Aria are administered 4 weeks apart. All following doses are administered once every 8 weeks. 

Administering Simponi Aria via IV Infusion  

1.  The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Simponi Aria Infusion Side Effects  

As with all medications, side effects are possible. 

Common side effects include: 

• Upper respiratory infection 
• Abnormal liver tests 
• Decreased blood cells that fight infection 
• Viral infections 
• Bronchitis 
• High blood pressure 
• Rash 

Serious side effects include: 

• Serious infections  
• Lymphoma 
• Cancer, including melanoma and hepatosplenic T-cell lymphoma 
• Heart failure 
• Nervous system problems 
• Lupus-like symptoms 
• Allergic reactions 

How To Prepare for a Simponi Aria Infusion  

It is essential that patients inform their physician if they currently have, or have had, any of the conditions listed below: 

• Heart problems 
• Serious or recurring infections 
• Psoriasis 
• Allergies to any of the ingredients in Simponi Aria 

How to Get a Referral for Simponi Aria IV Infusions  

Every Simponi Aria referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Simponi Aria IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Results of a recent tuberculosis (TB) skin/lab testing 
• Patient’s current weight and height 
• Clinicals to support one or more of the following: 
• Patient has moderately to severely active rheumatoid arthritis (RA) and is taking methotrexate 
• Patient has active psoriatic arthritis 
• Patient has active ankylosing spondylitis 

If you or someone you care about has one of the conditions that Simponi Aria infusions treat, you may want to learn more about IV infusion treatments with golimumab. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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Renflexis is a biologic therapy that is indicated to treat:

• moderately to severely active ulcerative colitis
• moderately to severely active Crohn’s disease
• moderately to severely active rheumatoid arthritis
• psoriatic arthritis
• ankylosing spondylitis
• plaque psoriasis

What Is Renflexis?  

Renflexis (infliximab-abda) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion.  

Renflexis is a biosimilar of Remicade. A biosimilar is a biologic therapy that has been approved and licensed by the FDA and has shown to have no clinically meaningful difference from an existing therapy, known as the “reference product.” 

How Renflexis Works  

 With certain health conditions, the immune system can overproduce a certain protein called tumor necrosis factor-alpha (TNF-alpha). Having too much TNF-alpha plays a role in the inflammation leading to some symptoms. Renflexis works by blocking the TNF-alpha actions and helps stop the underlying cause of inflammation. 

What Is Renflexis Used For?  

Doctors order infliximab-abda to treat several medical conditions. 

Renflexis treats: 

• moderately to severely active ulcerative colitis  
• moderately to severely active Crohn’s disease  
• moderately to severely active rheumatoid arthritis  
• psoriatic arthritis 
• ankylosing spondylitis 
• plaque psoriasis 

Renflexis Infusion Dosage and Administration  

Patients receive infliximab-abda intravenously. Treatment time for a Renflexis infusion at a medical clinic like IV LEAGUE INFUSION SERVICES usually lasts around 2 hours. 

Dosage and Frequency  

Before receiving their first intravenous infusion of infliximab-abda, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

Renflexis is administered via infusion in three starting doses within the first six weeks of your treatment. After the initial six weeks, patients will receive infusions once every six-eight weeks or every four weeks for some RA patients. 

Administering Renflexis via IV Infusion  

1.  The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Renflexis Infusion Side Effects  

As with all medications, side effects are possible.  

The most common side effects include: 

• Respiratory infections, such as sinus infections and sore throat 
• Headache 
• Coughing 
• Stomach pain 

Serious side effects include: 

• Serious infections 
• Heart failure 
• Other heart problems 
• Liver injury 
• Blood problems 
• Nervous system disorders 
• Allergic reactions 
• Lupus-like syndrome 
• Psoriasis 

How To Prepare for a Renflexis Infusion  

Before starting Renflexis, patients should tell their doctor if they: 

• Think they have an infection 
• Are being treated for an infection 
• Have signs of an infection 
• Have any open cuts or sores on the body 
• Get recurrent or a lot of infections 
• Have diabetes or an immune system problem 
• Have TB or have been in close contact with someone with TB 
• Live or have lived in certain parts of the country where there is an increased risk of getting certain kinds of fungal infections 
• Have or had Hepatitis B 
• Use the medicines Kineret (anakinra) Orencia (abatacept), Actemra (tocilizumab) or other medicines called biologics used to treat the same conditions as Renflexis

How to Get a Referral for Renflexis IV Infusions  

Every Renflexis referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Renflexis IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Result of Tuberculosis (TB) skin/ lab testing 
• Hepatitis B status & date 
• Patients current weight and height 
• Clinicals to support one or more of the following: 
• Patient has active moderate to severe Crohn’s disease (CD) 
• Patient has active moderately to severely active Ulcerative Colitis (UC) 
• Patient has Rheumatoid Arthritis (RA) 
• Patient has Psoriatic Arthritis 
• Patient has Ankylosing Spondylitis 
• Patient has Plaque Psoriasis 

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Nucala is a biologic therapy that is indicated to treat:

• Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype
• Add-on maintenance treatment of adult patients 18 years and older withchronic rhinosinusitis with nasal polyps (CRSwNP)
• The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA)
• The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause

What Is Nucala?  

Nucala (mepolizumab) is an injectable biologic monoclonal antibody used to treat patients with a variety of conditions, including severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), hypereosinophilic syndrome, and chronic rhinosinusitis with nasal polyps. 

How Nucala Works 

White blood cells called eosinophils make up a normal part of the body’s immune system. People with certain types of asthma can have too many eosinophils, leading to inflammation in the lungs and asthma attacks. 

Nucala works by reducing the number of eosinophils in the blood. 

What Is Nucala Used For?  

Doctors order mepolizumab to treat several medical conditions. 

Nucala treats: 

• Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype 
• Add-on maintenance treatment of adult patients 18 years and older with chronic rhinosinusitis with nasal polyps (CRSwNP) 
• The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA) 
• The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause 

Nucala Injection Dosage and Administration  

Patients receive Nucala via subcutaneous injection in the upper arm, thigh, or abdomen. 

Dosage and Frequency  

 Typical dosage is 100mg/mL. 

Injections are typically administered once every four weeks. 

Nucala Injection Side Effects  

As with all medications, side effects are possible. 

Side effects include: 

• Headache 
• Injection site reactions  
• Back pain 
• Fatigue 
• Allergic reactions

How To Prepare for a Nucala Injection 

It is essential that patients inform their physician if they: 

• Are taking oral or inhaled corticosteroids 
• Have a parasitic (helminth) infection 
• Are currently taking any other medications, including prescription and over-the-counter medicines, vitamins, and herbal supplements 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Nucala injection treatment at IV LEAGUE INFUSION SERVICES. 

How to Get a Referral for Nucala Injections 

Every Nucala referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Nucala injection therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• List of current medications treating disease 
• Labs showing elevated eosinophil count of 150 cells/uL or higher 
• Clinicals showing number of asthma exacerbations in the last 12 months 
• FEV1 test results 
• Clinicals to support one or more of the following:
  • Add-on maintenance treatment of adult patients 18 years and older with chronic rhinosinusitis with nasal polyps (CRSwNP) 
  • The treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA) 
  • The treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome (HES) for ≥6 months without an identifiable non-hematologic secondary cause 
  • Add-on maintenance treatment of adult and pediatric patients aged 6 years and older with severe asthma and with an eosinophilic phenotype

If you or someone you care about has one of the conditions that Nucala injections treat, you may want to learn more about injection treatments with mepolizumab. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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Lemtrada is a biologic therapy that is indicated to treat:

• relapsing forms of multiple sclerosis (MS) in adults who have tried two or more other MS medications that haven’t worked well enough

What Is Lemtrada?  

Lemtrada (alemtuzumab) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion for patients with multiple sclerosis (MS). 

How Lemtrada Works  

Lemtrada works by binding to CD52 on B and T cells, which are two key drivers thought to cause MS inflammation. Lemtrada depletes these cells from circulation. 

What Is Lemtrada Used For?  

Doctors order alemtuzumab to treat: 

• Relapsing forms of multiple sclerosis (MS) in adults who have tried two or more other MS medications that haven’t worked well enough 

Lemtrada Infusion Dosage and Administration  

Patients receive alemtuzumab intravenously. At a medical clinic like IV LEAGUE INFUSION SERVICES, each infusion takes approximately four hours with a two hour observation period afterwards. 

Dosage and Frequency  

Typical Lemtrada dosage is 12mg/1.2mL. 

Lemtrada infusions are administered in eight doses over two years, on five consecutive days in round one and, one year later, on three consecutive days in round two. 

Administering Lemtrada via IV Infusion  

1.  The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Lemtrada Infusion Side Effects  

As with all medications, side effects are possible.  

The most common side effects of Lemtrada include: 

• Rash or hives 
• Headache 
• Thyroid problems 
• Fever 
• Swelling of the nose and throat 
• Nausea and vomiting 
• Urinary tract infection 
• Feeling tired 
• Trouble sleeping 
• Upper respiratory infection 
• Herpes viral infection 
• Fungal infection 
• Joint pain or back pain 
• Pain in the arms or legs 
• Diarrhea 
• Sinus infection 
• Mouth pain or sore throat 
• Tingling sensation 
• Dizziness 
• Stomach pain 
• Sudden redness in face, neck, or chest 

More serious side effects include: 

• Autoimmune problems 
• Serious allergic reactions 
• Stroke and tears in arteries supplying blood to the brain 
• Cancer 

To decrease the likelihood of the patient experiencing a reaction, he or she may be advised to take certain medications before the next IV infusion treatment with alemtuzumab. 

How To Prepare for a Lemtrada Infusion  

It is essential that patients inform their physician if they: 

• Have bleeding, thyroid or kidney problems 
• Have a recent history of infection 
• Are taking a medicine called Campath (alemtuzumab) 
• Have received a live vaccine in the past 6 weeks before receiving Lemtrada 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Lemtrada IV infusion treatment at IV LEAGUE INFUSION SERVICES. 

During treatment with Lemtrada, patients need to avoid receiving live vaccines.

How to Get a Referral for Lemtrada IV Infusions  

Every Lemtrada referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Lemtrada IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Most recent lab results 
• Results of a recent tuberculosis (TB) skin/lab testing 
• Results of HIV testing 
• Patient has relapsing-remitting multiple sclerosis (RRMS) who has had an inadequate response to two or more drugs indicated for the treatment of MS 
• Baseline labs as required by REMS program 
• Results of Hep C testing 

If you or someone you care about has one of the conditions that Lemtrada infusions treat, you may want to learn more about IV infusion treatments with alemtuzumab. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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Givlaari is a biologic therapy that is indicated to treat:

• Adults with acute hepatic porphyria (AHP)

What Is Givlaari?  

Givlaari, also known as givosiran, is a subcutaneous injection used to treat patients with acute hepatic porphyria (AHP). 

How Givlaari Works  

In people with AHP, a genetic mutation causes heme production processes in the liver to not work properly. In the liver, this process is controlled by an enzyme called aminolevulinic acid synthase 1 (ALAS1). 

When ALAS1 is activated, the heme production process is unable to keep up. This causes toxic substances called aminolevulinic acid (ALA) and porphobilinogen (PBG) to build up. 

Givlaari reduces the amount of ALAS1 in the liver, which leads to a reduction in the levels of the toxins ALA and PBG. 

What Is Givlaari Used For?  

Doctors order givosiran to treat: 

• Adults with acute hepatic porphyria (AHP) 

Givlaari Injection Dosage and Administration  

Patients receive Givlaari via subcutaneous injection. 

Dosage and Frequency  

 Before receiving their first injection of givosiran, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which they are receiving treatment. 

Injections of Givlaari are typically administered once a month. 

Givlaari Injection Side Effects  

As with all medications,  side effects are possible.  

Common side effects include: 

• Nausea 
• Injection site reactions 
• Rash 
• Changes in kidney function 
• Changes in liver function 
• Fatigue 

More serious side effects include: 

• Blood homocysteine increase 
• Chronic kidney disease 
• Device breakage 
• Fever 
• Urinary tract infections 
• Severe allergic reactions 

How To Prepare for a Givlaari Injections  

It is essential that patients inform their physician if they currently have, or have had allergies to the ingredients in Givlaari. 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Givlaari injection treatment at IV LEAGUE INFUSION SERVICES. 

How to Get a Referral for Givlaari Injections 

Every Givlaari referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Givlaari injection therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Current height and weight 

If you or someone you care about has one of the conditions that Givlaari injections treat, you may want to learn more about subcutaneous injection treatments with givosiran. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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Entyvio is a biologic therapy that is indicated to treat:

• Moderate to severe Crohn’s disease in adults
• Moderate to severe ulcerative colitis in adults

What is Entyvio?

Entyvio (vedolizumab) is a unique gastrointestinal-focused biologic (aka GI-focused biologic). This integrin receptor antagonist is unique in that it is the only GI-focused biologic available for the treatment of moderately-to-severely active ulcerative colitis (UC) and Crohn’s disease (CD). Adult patients receive Entyvio as a solution that is administered via intravenous infusion (aka IV infusion).

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How Does Entyvio Work?

When an individual has Crohn’s disease or ulcerative colitis, an increase in the number of WBCs within the GI tract causes inflammation, which results in the development of the symptoms associated with CD and UC. Entyvio specifically targets the gastrointestinal tract to prevent excess WBCs from entering, thus controlling inflammation and reducing the symptoms of UC and CD.

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What is Entyvio Used For?

Although a physician may prescribe Entyvio for other reasons, this medication is typically used for the treatment of moderately-to-severely active Crohn’s disease or ulcerative colitis in adults.

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Entyvio Infusion Dosage and Administration

When starting Entyvio, the patient receives infusions at weeks 0, 2 and 6. After the sixth week, the patient receives infusions every 8 weeks. If a patient reaches week 14 and does not have evidence to prove he or she is benefitting from these treatments, Entyvio Infusion therapy should be discontinued.

While having an infusion of Entyvio, patients can expect the procedure to be identical to, or closely resemble, the steps below.

1. A nurse carefully inserts a small, very thin catheter into one of the patient’s arm veins.
2. Following insertion of the IV line, the nurse connects the tube coming down from the 300 mg bag or bottle of medication to the patient’s IV.
3. After connecting the tube to the patient’s IV, the Entyvio infusion begins.
4. An Entyvio infusion usually takes about 30 minutes.

During the infusion, patients are encouraged to relax, unwind, and enjoy themselves by catching up on a favorite show or surfing the web. If patients need assistance, simply press the call button, and one of the IV LEAGUE INFUSION SERVICES members will be right in.

Dependent on the prescribed regimen and tolerance from the patient, the nurse may initially begin the infusion at a lower concentration, slowly increasing the concentration of Entyvio as the treatment continues. On the day of their Entyvio infusion, patients may consider bringing a driver with them as the referring physician may want the patient to refrain from driving.

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Following the Infusion

Since serious allergic reactions may not become evident for several hours following treatment, patients need to have an adult remain with them overnight. Symptoms that warrant immediate treatment include a fast heart rate, shortness of breath, itching/a rash or flushing.

All medications can cause side effects.

Possible side effects following an Entyvio infusion include:

• A headache
• Back pain
• Symptoms similar to the common cold
• An upset stomach
• Joint pain
• Feeling weak or fatigued
• Pain in the extremities
• Irritation of the throat or nose

This is not a complete list of the possible side effects. Individuals who are concerned about experiencing side effects need to contact their physician for medical advice.

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How to Prepare for an Entyvio Infusion

As part of the preparation process for an Entyvio Crohn’s disease infusion or an Entyvio ulcerative colitis infusion, IV LEAGUE INFUSION SERVICES asks patients to review their Informed Consent document.

At the appointment for their first infusion, patients are asked to sign their Patient Financial Responsibility form. IV LEAGUE INFUSION SERVICES encourages all Entyvio patients to apply for the assistance program available through the manufacturer. Even if a patient has health insurance that covers the cost of this medication, the Entyvio Connect patient assistance program may reimburse the patient for his or her out-of-pocket expenses (up to $6,500 a year).

Patients must be up-to-date on all their immunizations. However, Patients should only have vaccinations/immunizations with their doctor’s consent. The doctor needs to know if the patient has had any immunizations recently. In addition, the treating physician needs details about the patient’s medical history. Especially relating to recurrent infections and diseases. (e.g., tuberculosis and cancer).

The patient must be healthy at the time of his or her infusion because Entyvio can make an existing infection worse. In addition, patients receiving Entyvio infusions are more vulnerable to contracting infections like the flu, chickenpox and measles. Patients need to avoid having contact with those who have recently received live vaccinations (e.g., the flu vaccine that people inhale through their nose).

Patients will need to inform their doctor of all the medications and products they take regularly. This list should include prescription and nonprescription medications as well as dosage amounts and frequency taken, if an individual takes herbal products and vitamins, please include these in the list as well.

Entyvio infusions should only be used when necessary during pregnancy. IV LEAGUE INFUSION SERVICES recommends discussing your treatment plan with your referring provider if you are pregnant or nursing.

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How to Get a Referral for Entyvio IV Infusions

Information IV LEAGUE INFUSION SERVICES needs to ensure attaining the patient referral for Entyvio infusions is a quick and seamless process.

Each referral must have:

• The Prescription for Treatment with Entyvio
  • The name of the provider and his or her NP#
  • The address of the provider
  • The phone number and fax number of the provider
  • An electronically authenticated signature or traditional written signature
• Patient Demographics
  • Patient’s name.
  • Patient’s phone number (e.g., home and mobile).
  • The patient’s address.
  • Applicable primary and secondary health insurance information.
  • Clinicals to support the patient’s need for treatment (e.g., lab tests and notes).
  • The weight and height of the patient.
  • The results of the patient’s recent tuberculosis test.
• Clinicals to support the patients need for treatment (e.g, lab tests and notes).

To learn more about treatment with Entyvio IV infusion, find your closest IV LEAGUE INFUSION SERVICES center here.

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• Evening & weekend appointments
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Cimzia is a biologic therapy that is indicated to treat:

• moderately to severely active rheumatoid arthritis (RA)
• active psoriatic arthritis
• active ankylosing spondylitis
• moderately to severely active Crohn’s disease (CD) with an inadequate response to conventional therapies
• moderately to severely active plaque psoriasis (PSO) with a candidacy for systemic therapy or phototherapy
• inflammatory arthritis [non-radiographic axial spondyloarthritis (nr-axSpA)]

What Is Cimzia?

Cimzia (certolizumab pegol) is an injectable biologic medication that is FDA-approved for use for patients who are at least 18 years of age. Cimzia contains the active drug certolizumab. This medication binds to tumor necrosis factor alpha (TNFα), blocking its ability to trigger inflammation.

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What Is Cimzia Used For?

Cimzia helps reduce the signs and symptoms of autoimmune diseases such as:

• Rheumatoid Arthritis: Rheumatoid arthritis causes joint inflammation, which results in pain, fever, and joint tenderness. Left untreated, the affected joints can begin deteriorating.
• Crohn’s Disease: Crohn’s disease is an Inflammatory Bowel Disease. Although Crohn’s disease can affect any part of the GI tract, it typically affects the ileum (small bowel) and a section of the colon (large bowel).
• Ankylosing Spondylitis (AS): People with ankylosing spondylitis frequently experience swelling, stiffness, and chronic pain in their low back.
• Inflammatory Arthritis: Individuals with non-radiographic axial spondyloarthristis (nr-axSpA) have the same symptoms as those with AS. However, any inflammation in the lower spine is undetectable on X-rays.
• Plaque Psoriasis: Plaque psoriasis causes skin inflammation. This inflammation leads to the development of pink or dark-colored skin patches (also referred to as plaques). Symptoms can include itching and pain.
• Psoriatic Arthritis: People who have psoriatic arthritis experience inflammation in their joints and skin.

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Cimzia Injection Administration and Dosing

Cimzia is available in two forms:

• A solution within a single-dose prefilled syringe that may be administered by a medical professional or at home by the patient. Each prefilled syringe holds 200mg of medication.
• A single-dose vial of Cimzia powder that a medical professional combines with sterile water before extracting it from the vial into a syringe for injection.

Cimzia injection sites include the front of the thighs and abdomen, at least 2 inches away from the navel. Cimzia is injected subcutaneously. Each new injection point must be at least 1 inch away from the last site used.

Dose and Frequency

Initially patients receive two 200mg injections of Cimzia. They receive the same 400mg dose again two weeks later and the third two injection dose two weeks after that.

Following the initial three doses, patients begin their Cimzia maintenance program. Maintenance doses are typically one injection every two weeks or two injections every four weeks.

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Side Effects of Cimzia Injections

Since Cimzia must decrease the effectiveness of the immune system to reduce inflammation, fighting off an infection can be more difficult. Patients need to inform their physician if they have any signs indicating an infection. Some of these signs include a cough, fever, or a rash that is red or painful. Patients with these symptoms, as well as those who are having surgery, may need to discontinue their Cimzia therapy until they recover from their infection or once their surgery is complete. Additionally, patients who have heart disease or similar symptoms should let their physician know before receiving Cimzia treatment.

Following an injection, individuals experiencing any of the signs or symptoms below should seek medical attention immediately, as this can indicate a serious reaction.

• Hives
• Rash
• Difficulty breathing
• Inflammation of the lips, eyelids, face, or tongue

Mild side effects of Cimzia include a respiratory infection, feeling tired, a urinary tract infection, a headache, joint pain and pain or redness at the injection site. Serious side effects of Cimzia include new or worsening symptoms of heart failure, hepatitis B reactivation, blood disorders, nerve problems that are new or previous nerve issues worsening, serious infections, and hair loss.

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How To Prepare for a Cimzia Injection

Before starting therapy with Cimzia, patients must have a negative tuberculosis (TB) test. During Cimzia therapy, patients should not receive live vaccines. The annual flu shot is safe to take because it does not contain a live virus.
Patients need to provide their treating physician with the names, doses, and frequency of their other medications they take, as well as their vitamins and herbal supplements.

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How to Get a Referral for Cimzia Injections

Every Cimzia referral must be accompanied by a physician’s order for treatment.

Patient information should include:

• Name
• Current address
• Home and mobile phone number
• Insurance information

Information the physician must include on the patient’s order for Cimzia injection therapy:

• Patient’s name and DOB
• Order date
• Diagnosis
• Physician’s name and NPI#
• Office address, phone and fax numbers
• Provider’s signature

Supporting clinical documentation from the physician should include:

• Results of a recent tuberculosis (TB) skin/lab testing
• Patient’s current weight and height

Clinicals to support one or more of the following:

• Patient has moderately to severely active rheumatoid arthritis (RA)
• Patient has active psoriatic arthritis
• Patient has active ankylosing spondylitis
• Patient has active moderately to severely Crohn’s disease who has had an inadequate response to conventional therapy
• Patient has moderate to severe plaque psoriasis (PSO) who is a candidate for systemic therapy or phototherapy

If you or someone you care about has one of the conditions that Cimzia injections treat, you may want to learn more about biologic injection treatments. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here.

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Avsola is a biologic therapy that is indicated to treat:

• moderately to severely active ulcerative colitis
• moderately to severely active Crohn’s disease
• moderately to severely active rheumatoid arthritis
• psoriatic arthritis
• ankylosing spondylitis
• plaque psoriasis

What Is Avsola?  

Avsola (infliximab-axxq) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion. Infliximab-axxq is used to treat a variety of complex chronic conditions. Avsola is also a biosimilar of Remicade. A biosimilar is a biologic therapy that has been approved and licensed by the FDA and has shown to have no clinically meaningful difference from an existing therapy, known as the “reference product.” 

How Avsola Works  

Inflammatory immune diseases cause the body to make too much of a protein called tumor necrosis factor-alpha (TNF-α). This can cause the immune system to attach healthy parts of the body, leading to inflammation and pain. 

Avsola works by targeting and blocking extra TNF-α to help relieve symptoms like inflammation and prevent further joint damage. 

What Is Avsola Used For?  

Doctors order infliximab-axxq to treat several medical conditions. 

Avsola treats: 

• moderately to severely active ulcerative colitis  
• moderately to severely active Crohn’s disease  
• moderately to severely active rheumatoid arthritis  
• psoriatic arthritis 
• ankylosing spondylitis 
• plaque psoriasis 

Avsola Infusion Dosage and Administration  

Patients receive infliximab-axxq intravenously. Treatment time for an Avsola infusion at a medical clinic like IV LEAGUE INFUSION SERVICES usually lasts for around 2 hours. 

Dosage and Frequency 

Avsola dosage depends on the condition it is being used to treat. Avsola is administered via infusion in three starting doses within the first six weeks of your treatment. After the initial six weeks, patients will receive infusions once every six to eight weeks or every four weeks for some RA patients. 

Administering Avsola via IV Infusion  

1. The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Avsola Infusion Side Effects  

As with all medications, side effects are possible.  

Common side effects include: 

• Respiratory infections (sinus infections and sore throat) 
• Headache 
• Rash 
• Coughing  
• Stomach pain 

Other rarer side effects include: 

• Severe infections 
• Cancer 
• Injury to the liver 
• Blood disorders 
• Neurologic disease 
• An allergic reaction to the protein in infliximab-axxq 

Following treatment, patients need to inform their referring doctor if they develop skin growths, as well as open or painful sores. In addition, the physician needs to know if the patient is experiencing flu-like symptoms or has a poor appetite. 

How To Prepare for an Avsola Infusion  

It is essential that patients inform their physician if they currently have, or have had, any of the conditions listed below: 

• Heart failure 
• Tuberculosis 
• Cancer 
• Serious infections 
• Blood problems 
• A liver injury 
• Hepatitis B 
• A nervous system disorder (e.g., multiple sclerosis or seizures) 
• Are allergic to any of Avsola’s ingredients 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Avsola IV infusion treatment at IV LEAGUE INFUSION SERVICES. 

During treatment with Avsola, patients need to avoid receiving live vaccines. 

How to Get a Referral for Avsola IV Infusions  

Every Avsola referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Avsola IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Result of Tuberculosis (TB) skin/ lab testing 
• Hepatitis B status & date 
• Patients current weight and height 
• Clinicals to support one or more of the following: 
• Patient has active moderate to severe Crohn’s disease (CD) 
• Patient has active moderately to severely active Ulcerative Colitis (UC) 
• Patient has Rheumatoid Arthritis (RA) 
• Patient has Psoriatic Arthritis 
• Patient has Ankylosing Spondylitis 
• Patient has Plaque Psoriasis 

If you or someone you care about has one of the conditions that Avsola infusions treat, you may want to learn more about IV infusion treatments with infliximab-axxq. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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• Big screen TVs, high-speed WiFi, free snacks

Vyepti is a biologic therapy that is indicated to treat:

• Adults with chronic migraines

What Is Vyepti? 

Vyepti (eptinezumab-jjmr) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion. 

How Vyepti Works  

There is a protein inside the body called calcitonin gene-related peptide (CGRP) that activates specific receptors on cells and may play a role in chronic migraines.  

Vyepti works by binding to CGRP and blocking it from activating those receptors. 

What Is Vyepti Used For?  

Doctors order eptinezumab-jjmr to treat: 

• Adults with chronic migraines 

Vyepti Infusion Dosage and Administration  

Patients receive eptinezumab-jjmr intravenously. Treatment time for a Vyepti infusion at a medical clinic like IV LEAGUE INFUSION SERVICES usually lasts for 30 minutes. Vyepti requires dilution prior to administration. 

Dosage and Frequency  

The recommended dosage is 100 mg administered by intravenous infusion every 3 months. Some patients may benefit from a dosage of 300 mg administered by intravenous infusion every 3 months. 

Administering Vyepti via IV Infusion  

1. The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication.  

Vyepti Infusion Side Effects  

As with all medications, side effects are possible.  

Common side effects include: 

• Stuffy nose and scratchy throat 
• Allergic reaction 

How To Prepare for a Vyepti Infusion  

It is essential that patients inform their physician if they: 

• Have any medical conditions 
• Are currently taking medications, including any prescription and over-the-counter medicines, vitamins, or herbal supplements 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Vyepti IV infusion treatment at IV LEAGUE INFUSION SERVICES. 

How to Get a Referral for Vyepti IV Infusions  

Every Vyepti referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Vyepti IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Clinicals to support an indication for the preventive treatment of migraines in adult patients 
• Patient has a history of migraines and has been on 2 oral preventatives and has experienced 4 or more migraines within a month period 

If you or someone you care about has one of the conditions that Vyepti infusions treat, you may want to learn more about IV infusion treatments with eptinezumab-jjmr. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

• ALL private suites
• Comfortable recliners, with chairs for guests
• Evening & weekend appointments
• Friendly clinical staff deliver personal service
• Big screen TVs, high-speed WiFi, free snacks