Krystexxa is a biologic therapy that is indicated to treat:

• chronic gout in adults who haven’t responded to other therapies

What Is Krystexxa?  

Krystexxa (pegloticase) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion to help reduce symptoms of gout. 

How Krystexxa Works  

In patients with gout, uric acid builds up in the joints, causing the symptoms of the disease. Krystexxa works by lowering uric acid levels in the body and removing uric acid crystal buildup in the joints. 

What Is Krystexxa Used For?  

Doctors order pegloticase to treat: 

• chronic gout in adults who haven’t responded to other therapies 

Krystexxa Infusion Dosage and Administration  

Patients receive pegloticase intravenously. Treatment time for a Krystexxa infusion at a medical clinic likeIV LEAGUE INFUSION SERVICES usually lasts roughly two hours. 

Dosage and Frequency  

Typical dosage of Krystexxa is 8 mg/mL.  

Krystexxa is generally administered once every two weeks. 

Administering Krystexxa via IV Infusion  

1.  The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals.

Krystexxa Infusion Side Effects  

As with all medications, side effects are possible. 

Common side effects of Krystexxa include: 

• Gout flare-ups or attacks 
• Allergic reactions 
• Nausea 
• Bruising 
• Sore throat 
• Constipation 
• Chest pain 
• Vomiting  

Patients should inform their referring physician if they experience serious side effects. 

Serious side effects include: 

• Wheezing, shortness of breath, or coughing 
• Chest tightness or trouble breathing 
• Reddening of the face 
• Itching 
• Hives 
• Feeling warm 
• Swelling of the throat or tongue 
• Throat tightness 
• Hoarse voice 
• Trouble swallowing 

How To Prepare for a Krystexxa Infusion  

It is essential that patients inform their physician if they currently have, or have had, any of the conditions listed below: 

• G6PD deficiency 
• Heart problems 
• High blood pressure 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Krystexxa IV infusion treatment at IV LEAGUE INFUSION SERVICES. 

How to Get a Referral for Krystexxa IV Infusions 

Every Krystexxa referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Krystexxa IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis 
• Physician’s name and NPI# 
• Office address, phone, and fax numbers 
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Perform serum uric acid (sUA) test prior to each infusion 
• Screen patients at risk for G6PD deficiency prior to starting therapy 
• Patient had chronic gout and is an adult patient who have failed to normalize serum or has shown an inadequate response to conventional therapy 

If you or someone you care about has one of the conditions that Krystexxa infusions treat, you may want to learn more about IV infusion treatments with pegloticase. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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