Ultomiris is a biologic therapy that is indicated to treat:

• adult patients with paroxsymal nocturnal hemoglobinuria (PNH)
• adults and pediatric patients one month of age and older with atypical hemolytic uremic syndrome (aHUS)

What Is Ultomiris?  

Ultomiris (ravulizumab-cwvz) is a prescription medication administered for patients in all IV LEAGUE INFUSION SERVICES centers via IV infusion. 

How Ultomiris Works  

 Ultomiris works by binding to the complement protein C5 to block its activation ad remove it from the bloodstream. By biding and eliminating C5, Ultomiris controls intravascular hemolysis (IVH) of paroxysmal nocturnal hemoglobinuria (PNH). 

What Is Ultomiris Used For?  

Doctors order ravulizumab-cwvz to treat: 

• adult patients with paroxysmal nocturnal hemoglobinuria (PNH) 
• adults and pediatric patients one month of age and older with atypical hemolytic uremic syndrome (aHUS) 

Ultomiris Infusion Dosage and Administration  

Patients receive ravulizumab-cwvz intravenously. Treatment time for an Ultomiris infusion at a medical clinic like IV LEAGUE INFUSION SERVICES usually lasts around 2 hours for adults and 4 hours for children. 

Dosage and Frequency  

Before receiving their first intravenous infusion of ravulizumab-cwvz, the ordering physician determines the patient’s dose. This dose depends on the patient’s weight as well as the severity of the condition for which he or she is receiving treatment. 

Ultomiris is typically administered every 8 weeks. 

Administering Ultomiris via IV Infusion  

1.  The nurse prepares the patient’s arm by using rubbing alcohol to sterilize the location that is being used to insert the IV needle. 
2. Following needle insertion, the IV line is held in place with tape. 
3. The nurse attaches the patient’s IV line to the line coming down from the bag of medication. 

Every half-an-hour, the patient’s nurse takes his or her vitals. 

Ultomiris Infusion Side Effects  

As with all medications, side effects are possible. 

Common side effects include: 

• Upper respiratory tract infection  
• Headache  

Other serious side effects include: 

• Infusion-related reactions 
• Serious infections 

How To Prepare for an Ultomiris Infusion  

It is essential that patients inform their physician if they: 

• Have an infection or fever 
• Are currently taking any medications including prescription and over-the-counter medicines, vitamins, and herbal supplements 

Before treatment, patients should get a good night’s sleep. In addition, they need to drink an adequate amount of fluid and eat a meal before their Ultomiris IV infusion treatment at IV LEAGUE INFUSION SERVICES. 

How to Get a Referral for Ultomiris IV Infusions  

Every Ultomiris referral must be accompanied by a physician’s order for treatment. 

• Patient information should include: 
• Name 
• Current address 
• Home and mobile phone number 
• Insurance information 

Information the physician must include on the patient’s order for Ultomiris IV therapy: 

• Patient’s name and DOB 
• Order date 
• Diagnosis Physician’s name and NPI# 
• Office address, phone, and fax numbers
• Provider’s signature 

Supporting clinical documentation from the physician should include: 

• Patient has been immunized with meningococcal vaccines at least 2 weeks prior to administering the first dose of Ultomiris 
• Clinicals to support one or more of the following: 
• Patient has Paroxysmal Nocturnal Hemoglobinuria (PNH) 
• Patient has atypical Hemolytic Uremic Syndrome (aHUS) 

If you or someone you care about has one of the conditions that Ultomiris infusions treat, you may want to learn more about IV infusion treatments with ravulizumab-cwvz. To find an IV LEAGUE INFUSION SERVICES infusion center near you, please click here. 

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